Semaglutide Pen Prefilled Syringe Filling Machine

KSP2 type cartridge filling and sealing machine

1)Main use and scope of application:

This machine is mainly used for plugging, filling and cap sealing of 0.5-3ml bottle in the pharmaceutical industry.

This machine adopts four-station step-type transmission system and intermittent disc rotating dial structure to automatically complete the complete production process from auger entering, filling, filling, capping and sealing.

2)technical parameter:

a. Applicable specifications: 0.5-3ml cartridge

b. Production capacity: 2000-3000 bottles / hour

c. Number of filling head:2

c. Number of capping head: 1

e. Number of stoppering head:1

f. Filling accuracy: up to ±2%

g. Passage pass rate: ≥99%

h. Rolling pass pass rate: ≥99%

i. Electric power rate: 2kw 380V~400v 60Hz

j. Machine weight: 850kg

k. Dimensions: 1950mm × 1890 × 1850mm (L × W × H)

3)working principle

a. This machine is a four-station step-type transmission system, and the intermittent disc rotating dial structure is sent to each process step by step in a group of 1 bottle, and the separation and delivery of the bottle is automatically completed, and the bottle is filled and filled. The process of medicine, cap sealing and the like is suitable for filling and sealing of the bottle type bottle under aseptic conditions.

b. This machine adopts the disc dial to intermittently fill and seal and seal the cap. The cassette bottle from the sterilizing dryer moves forward to the auger part through the bottle conveyor belt, and the auger organizes the disordered state of the bottle into an orderly separation state, and advances the bottle bottles one by one to the right. Into the bottle dial, the bottle puller intermittently delivers the bottle to the intermittently rotating disc wheel member, and a photoelectric detecting switch is arranged at the station, which can control the bottle without the plug function, and the disc dial will be used. The bottles are sent to the following three intermittent stations in a stepwise manner. The three intermittent stations are in turn: the bottom plug station, the filling station, and the cap sealing station.

At the stoppering position, the rubber stopper hopper aligns the rubber plugs in an orderly state into an ordered state, and advances the rubber stoppers one by one to the rubber stopper locators. When the disc wheel member transfers the cassette bottle to the stop position intermittently in the form of stepping, the stopper push rod is lifted from the bottom dead center, and the upper stop plate plate blocks the bottle from moving up, and at the same time, the inner tapered guide The sleeve is inserted into the bottom of the bottle to push the rubber stopper into the bottle. The plug is quickly returned from the top dead center to the starting point, completing the whole process of the plugging.

A photoelectric detection switch is provided at the station after the stopper, and the non-filling function can be controlled.

At the filling station, when the disc wheel member transfers the cassette bottle to the filling station intermittently in a stepwise manner, two new Peristaltic pumps pass through the filling needle. Driven down from the top dead center, insert the bottle into the bottle to inject the liquid into the bottle, and the liquid is returned from the bottom dead center to the top dead center. The filling pump capacity can automatically change the liquid loading by adjusting the touch screen parameters.

In the capping station, the oscillating hopper supplies the aluminum cover to the capping orbiter, and when the bottle is delivered to the capping station, the cap is covered by the bottom of the track orbiter, and the cap is covered by the cap. When the capping station is intermittently paused, the two capping heads are pressed down by the top dead center under the action of the cam, and the aluminum cap is rolled around the three-knife rolling cylinder to complete the capping action. The rolled cap is pushed into the bottle tray through the bottle dial, and the movement is repeated.

4)Performance characteristics:

a. The standard configuration of the filling system of this machine is a new type of Peristaltic pumps. It is corrosion resistant and the filling accuracy can be Up to 2%, It is very convenient to disassemble, install, clean and sterilize. It is easy and quick to use without any tools. The peristaltic pump is the most advanced, simplest and most reliable filling pump in the world.

d. The stopper head, the rubber stopper locator and the oscillating hopper are all made of stainless steel. The parts are easy to disassemble and install, easy to clean and disinfect, and have no bottle and no plug, no plug and no filling protection.

c. The capping head adopts a three-knife type flexible rolling knife structure, and the three-knife type flexible rolling knife rolls the aluminum cap around the bottle planetary rolling, does not damage the bottle and the cap, and the sealing is tight.

d. Parts disassembly and cleaning and disinfection: the design also fully considers the disassembly, cleaning and disinfection of parts. All parts in contact with the liquid medicine are made of 316L material or silicone tube material, and are connected by sanitary pipes without hygienic dead angle. The inner wall of the pipe is smooth and flat, and there is no chemical reaction or absorption that changes the safety, uniformity, potency or content, quality or purity of the drug.

e. Adopt advanced PLC man-machine interface control system control, in addition to the control and monitoring display of the machine work, it can also control the working condition with the washing machine and dryer of the previous process, and realize the linkage production well. . With bottleless irrigation, production speed display, production count, working time display, fault display function, in addition: filling volume, stopper position can be adjusted on the touch screen.

f. The needle tube in contact with the liquid medicine is made of 316L stainless steel material, and the pipeline adopts high quality silicone tube which meets the requirements, which fully meets the requirements of GMP regulations.

g. The main control electrical appliances and low-voltage electrical, all adopt branded electrical appliances, and the advanced reliability of electronic control has a good guarantee.

h. Clean and hygienic exterior design: The parts on the platen are made of 304 stainless steel and POM polyacetal. It has the characteristics of no dead angle, easy to clean and disinfect. The outer cover plates adopt international popular stainless steel sanding plate. High grade, in line with GMP standards.

Main configuration: